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KMID : 1149220190270040269
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Korean Journal of Oriental Medical Prescription
2019 Volume.27 No. 4 p.269 ~ p.284
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Anti-obesity effects of cultivated ginseng, -wild simulated ginseng and -red ginseng extracts
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Kim Ha-Rim
Lee Chang-Hyun
Jung Mun-Yhung
Kim Jong-Seok
Kim Hong-Jun
Jeon Hye-Sook
Lee Seung-Hyun
Kim Ji-Hyun
Shin Min-Ji
Ma Sang-Yong
Kwon Jin
Oh Chan-Ho
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Abstract
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This study was to investigate whether cultivated ginseng (CG), cultivated wild simulated ginseng (CWG) and cultivated red ginseng (CRG) extracts influences on the obesity. The saponin contents of 3 kinds of ginsengs were analysed by HPLC?ESI-TOF-MS. Total saponin contents were determined in CG on the most contents and since red ginseng has the highest PD (protopanaxadiol type) / PT (protopanaxatriol type) ratio, there may be differences between ginseng, wild ginseng, and red ginseng with respect to their pharmacological effects. Male C57BL/6J mice were fed a normal diet(N), HFD (60% Kcal fat, C), HFD with CG, CWG and CRG extracts (800 ㎎/kg) for 5 weeks. We observed change of total body weight, degree of hepatic lipid accumulation and immunohistochemical change of GLP-1 and insulin-secreting cells. Also this study attempts to use the physiological analysis method to analyze the changes of blood lipids, insulin and leptin concentration. The change of body weight and size of accumulated lipid droplets in liver lobules decreased in all of the experimental groups than the control(C) group. In the pancreas, the immunohistochemical density of insulin-secreting cells were significantly stronger in the CWG and CRG than C group. The levels of serum insulin and leptin significantly decreased 55.6%, 54.3% respectively in CWG and CRG. The changes of triglyceride, total cholesterol in serum decreased in CRG than the C group. Obesity related CG, CWG and CRG extracts might have contribute to improvement of obesity by regulating the levels of blood lipids and biochemical indicator of fat accumulation.
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KEYWORD
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cultivated ginseng, cultivated wild simulated ginseng, cultivated red ginseng, anti-obesity, leptin, insulin, lipids
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